Welche Medikamente sind riskant?

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G6PD-Info Kinderblutkrankheiten.de
G6PD-Info orphananesthesia.eu
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NameRisikostufeunsichersicher*MolekularformelNotizFür wen
2-NaphtholHighC10 H8 OAll
Acetanilide (acetanilid)HighC8 H9 N OMedit., Asia
AcetazolamideMediumC4 H6 N4 O3 S2All
Acetophenetidin (phenacetin)Low- All
Acetylphenylhydrazine (2-Phynylacetohydrazide)HighC8 H10 N2 OThese substances taken in high quantities might cause hemolysis also with normal subjects.All
Aldesulfone sodium (sulfoxone)HighC14 H14 N2 Na2 O6S3All
Aminophenazone (aminopyrine)MediumC13 H17 N3 OAll
Aminopyrine (Pyramidon, amidopyrine)Low- All
Antazoline (antistine)MediumC17 H19 N3All
AntipyrineLow- All
Arginine (2-Amino-5-guanidinopentanoic acid)MediumC6 H14 N4 O2All
ArsineHighAs-H3These substances taken in high quantities might cause hemolysis also with normal subjects.All
Ascorbic AcidHighC6 H8 O6All
Azathioprine (use with caution)Low- Use with caution and not in combination with other drugs.All
Baclofen (use with caution)Low- Use with caution and not in combination with other drugs.All
Bean of St.Ignatius (Strychnos ignatii)Medium- All
BenorilateMediumC17 H15 NO5All
BenzexoloLow- All
Beta-Naphthol (2-Naphthol)HighC10 H8 OAll
BrinzolamideHigh- See https://marineyes.com/glaucoma/medications.htmlAll
BupivacaineHighC18 H28 N2 OAll
Calcium CarboxylateMedium- All
CarbutamideMediumC11 H17 N3 O3 SAll
ChloramphenicolHighC11 H12 C12 N2 O5Medit., Asia
ChloroquineHighC18 H26 Cl N3If required, this substance may be taken under medical supervision as a preventive treatment or cure of malaria.Medit., Asia
Chloroquine + ProguanilHigh- Medit., Asia
CiprofloxacinHigh- All
ClorguanidinaLow- All
ColchicineMediumC22 H25 N O6All
Dapsone (diaphenylsulfone)HighC12 H12 N2 O2 SThese substances taken in high quantities might cause hemolysis also with normal subjects.All
DiethylamineHighC4 H11 NAll
DimenidrinatoHighC24 H28 ClN5 O3All
DimercaprolHighC3 H8 O S2All
DiphenhydramineLow- All
Diphenhydramine (difenilhydramine)MediumC17 H21 N OAll
Dopamine MediumC8 H11 N O2All
Dorzolamide High- See https://marineyes.com/glaucoma/medications.htmlAll
DoxorubicinHighC27 H29 N O11Medit., Asia
EnoxacinHighC15 H17 F4 N4 O3All
EpirubicinMediumC27 H29 NO11All
FlumequineMediumC14 H12 FNO3All
FurazolidoneHighC8 H7 N3 O5All
GlibenclamideHighC32 H28 Cl N3 O5 SHemolytic reactions to this substance have been reported only in few, isolated cases and no written reference exists as of this time.Medit., Asia
GlibornurideMediumC18 H26 N2 O4 SAll
GliclazideHighC15 H21 N3 O3 SAll
GlimepirideHighC24 H34 N4 O5 SAll
GlipizideHighC21 H27 N5 O4 SAll
Glucosulfone (glucosulfone sodium)HighC24 H34 N2 Na2O18 S3All
HydroxychloroquineHighC18 H26 ClN3 OAll
Indigofera TinctoriaMedium- All
Isobutyl NitriteHighC4 H9 N O2Medit., Asia
IsoniazidMediumC6 H7 N3 OAll
Lawsone InermisMedium- All
LevodopaMediumC9 H11 NO4All
LevofloxacinHighC18 H20 FN3 O4Medit., Asia
LomefloxacinHighC17 H19 F2 N3 O3All
MefloquineHighC17 H16 F6 N2 OAll
Menadiol Sodium Sulfate (Vitamin k4 sodium sulfate)HighC11 H8 Na2 O8 S2Synthetic substitutes of natural Vitamin K. Other substitutes non listed here are: menadiole diacetate, menadiole sodium phosphate (anhydrous salt). As treatment of hemorrhage in newborns, a single dose of this substance may be given (via parenteral) on the first day after birth and is well tolerated. The writers of these note (2,16) generally consider all Vitamin K substitutes as potentially hemolysis inducing substances. It is probable that natural Vitamin K1 (phyto-menadione) presents a lower risk.All
Menadione (menaphtone)HighC11 H8 O2Synthetic substitutes of natural Vitamin K. Other substitutes non listed here are: menadiole diacetate, menadiole sodium phosphate (anhydrous salt). As treatment of hemorrhage in newborns, a single dose of this substance may be given (via parenteral) on the first day after birth and is well tolerated. The writers of these note (2,16) generally consider all Vitamin K substitutes as potentially hemolysis inducing substances. It is probable that natural Vitamin K1 (phyto-menadione) presents a lower risk.All
Menadione sodium Bisulfite (Vitamin K3 sodium bisulfite)HighC11 H8 O2 NaHSO3Synthetic substitutes of natural Vitamin K. Other substitutes non listed here are: menadiole diacetate, menadiole sodium phosphate (anhydrous salt). As treatment of hemorrhage in newborns, a single dose of this substance may be given (via parenteral) on the first day after birth and is well tolerated. The writers of these note (2,16) generally consider all Vitamin K substitutes as potentially hemolysis inducing substances. It is probable that natural Vitamin K1 (phyto-menadione) presents a lower risk.All
Mepacrine (Quinacrine)HighC23 H3 O Cl N3 OMedit., Asia
Mesalazine - 5-Aminosalicylic Acid (paraminosalicylic acid)HighC7 H7 N O3Medit., Asia
MetamizoleHighC13 H16 N3 NaO4 SMedit., Asia
Methyltioninium Chloride (methylene blue)HighC16 H18 Cl N3 SAll
MorpholineMediumC4 H9 NOAll
MoxifloxacinHigh- Medit., Asia
Nalidixic AcidHighC12 H12 N2 O3Hemolytic reactions to this substance have been reported only in few, isolated cases and no written reference exists as of this time.Medit., Asia
Naphtalene, Pure (naphtalin)HighC10 H8All
NiridazoleHighC6 H6 N4 O3 SAll
Nitric OxideHighNOAll
Nitrofural (nitrofurazone)HighC6 H6 N4 O4All
NitrofurantoinHighC8 H6 N4 O5All
Nitroglycerin HighC3 H5 N3 O9All
NoramidopyrineHighC13 H16 N3 NaO4 SAll
NorfloxacinMediumC16 H18 F N3 O3All
O-Acetylsalicylic Acid (acetylsalicylic acid)HighC9 H8 O4Among the alternatives are Paracetamol, which is generally considered safe, and flurbiprophene.Medit., Asia
O-Acetylsalicylic Acid + AcetanilideHigh- Medit., Asia
O-Acetylsalicylic Acid + Ascorbic AcidHigh- All
O-Acetylsalicylic Acid + ParacetamolHigh- Beware of
- genetic G-6-PD deficiency (favism)
   - After paracetamol administration, hemolytic anemia may occur due to the reduced supply of glutathione
All
OfloxacinHigh- Medit., Asia
Oxidase, Urate (urate oxidase)High- Medit., Asia
PamaquineHighC42 H45 N3 O7All
Para-Aminobenzoic Acid (4-Aminobenzoic Acid)MediumC7 H7 N O2All
Paracetamol (acetaminophen)MediumC8 H9 N O2All
Paracetamol + PropyphenazoneMedium- All
PefloxacinHighC17 H20 N3 O3All
PentaquineHighC18 H27 N3 OAll
Phenacetin (acetophenetidin)HighC10 H13 N O2Probably safe in moderate doses.Medit., Asia
Phenazone (antipyrine)MediumC11 H12 N2 OAll
PhenazopyridineHighC11 H11 N5Medit., Asia
PhenylbutazoneMediumC19 H20 N2 O2All
PhenytoinMediumC19 H20 N2 O2All
PhynylhydrazineHighC6 H8 N2All
Phytomenadione (Vitamin K1)MediumC31 H46 O2All
Pipemidic AcidHighC14 H17 N5 O3All
Pregabalin (use with caution)Low- Use with caution and not in combination with other drugs.All
PrilocaineMediumC13 H20 N2 OAll
PrimaquineHighC15 H21 N3 OMay be given in reduces doses under medical supervision.All
ProbenecidHighC13 H19 NO4 SAll
ProcainamideMediumC13 H21 N3 OAll
Procainamide HydrochlorideLow- All
Proguanil (chlorguanidine)MediumC11 H16 Cl N5All
Propylene GlycolMediumC3 H8 O2All
Propyphenazone Medium- All
PyrimethamineMediumC12 H13 Cl N4All
QuinidineMediumC20 H24 N2 O2All
Quinidine + PhynylhydrazineHigh- All
Quinidine + QuinineMedium- All
QuinineMediumC20 H24 N2 O2All
RasburicaseHigh- Helps clear uric acid from the blood.Medit., Asia
Sodium nitroprusside HighNa2 [Fe(CN)5 NO]All
SpiramycinHighC43 H74 N2 O14All
Stibophen (2-(2-Oxido-3,5-Disulphonatophenoxy)-1,3,2,Benzodioxastibole-4-6-Disulphonate)HighC12 H4 Na5 O16 S4SbAll
StreptomycinMediumC21 H39 N7 O12All
SuccimerMediumC4 H6 O4 S2All
SulfacetamideHighC8 H10 N2 O3 SAll
SulfacytineMediumC12 H14 N4 O3 SAll
SulfadiazineMediumC10 H10 N4 O2 SAll
SulfadiazineMedium- Medit., Asia
Sulfadiazine + TrimethoprimMedium- All
SulfadimidineHighC12 H14 N4 O2 SAll
SulfadoxineMediumC12 H14 N4 O4 SAll
Sulfafurazole (sulfafurazone, sulfisoxazole)HighC11 H13 N3 O3 SMedit., Asia
SulfaguanidineMediumC7 H10 N4 O2 SAll
SulfamerazineMediumC11 H12 N4 O2 SAll
SulfamethizoleMediumC9 H10 N4 O2 S2All
SulfamethoxazoleHighC10 H11 N3 O3 SA component, together with Trimetroprim, of Co-trimoxazole.All
SulfamethoxypyridazineMediumC11 H12 N4 O3 SAll
Sulfanilamide (Sulphanilamide)HighC6 H8 N2 O2 SAll
SulfapyridineHighC11 H11 N3 O2 SAll
Sulfasalazine, Salazosulfapyridine (salazopyrin)HighC18 H14 N4 O5 SFor treating Ulcerative Colitis, Crohn's Disease, Rheumatoid Arthritis, Fibromyalgia.All
Sulfisoxazole (Gantrisin)Low- All
SulfoxoneMediumC14 H16 N2 O6 S3All
ThiamphenicolHighC12 H15 Cl2 NO5 SAll
Thiazosulfone (thiazolesulfone)HighC9 H9 N3 O2 S2Medit., Asia
Tiaprofenic AcidMediumC14 H12 O3 SAll
Tolonium Chloride, Tolonium Chloride (toluidine blue)HighC15 H16 Cl N3 SAll
Trihexyphynidyl (benzhexol)MediumC20 H31 N OAll
TrimethoprimMediumC14 H18 N4 O3Component, together with Sulfametossazole, of Co-trimoxazolo.All
Trimethoprim + Sulfamethoxazole High- All
Trinitrotoluene (2,4,6-Trinitrotoluene)HighC7 H5 N3 O6Medit., Asia
TripelennamineMediumC16 H21 N3Medit., Asia
Alfentanileingeschränkt sicher - siehe weiter rechts[33]
Ascorbinsäureeingeschränkt sicher - siehe weiter rechts[6, 10, 17, 18, 46]
ASS (low dose)eingeschränkt sicher - siehe weiter rechts[3, 6, 10, 17, 18, 39, 46]
Chloramphenicoleingeschränkt sicher - siehe weiter rechts[6, 10, 17, 18, 39, 46]
Fentanyleingeschränkt sicher - siehe weiter rechts[2, 12,15, 17, 24, 26, 33, 37, 44]
Glibenclamideingeschränkt sicher - siehe weiter rechts[46]
Isofluraneingeschränkt sicher - siehe weiter rechts[12, 15, 26, 40, 44]
Isoniazideingeschränkt sicher - siehe weiter rechts[6, 17, 18, 46]
Metamizoleingeschränkt sicher - siehe weiter rechts[46]
Midazolameingeschränkt sicher - siehe weiter rechts[2,12, 17, 26, 44]
Nitroprussideingeschränkt sicher - siehe weiter rechts[34]
Paracetamoleingeschränkt sicher - siehe weiter rechts[10.19, 31, 44, 46]
Penicillineingeschränkt sicher - siehe weiter rechts[24]
Prilocaineingeschränkt sicher - siehe weiter rechts[17, 18, 46]
Remifentanileingeschränkt sicher - siehe weiter rechts[33]
Sevofluraneingeschränkt sicher - siehe weiter rechts[26,37,44]
Streptomycineingeschränkt sicher - siehe weiter rechts[6, 17, 18, 46]
Trimethoprimeingeschränkt sicher - siehe weiter rechts[6, 17, 18, 46]
Vitamin Keingeschränkt sicher - siehe weiter rechts[6, 10, 18, 46]
AlfentanilHigh[17]
AscorbinsäureHigh[10, 15, 46]
ASS (low dose)High[10, 11, 15, 35, 46]
ChloramphenicolHigh[3, 10, 11, 15, 46]
FentanylHigh[33]
GlibenclamidHigh[6, 46]
IsofluranHigh[4,17]
IsoniazidHigh[15, 46]
MetamizolHigh[6,15, 46]
MidazolamHigh[4]
NitroprussidHigh[40]
ParacetamolHigh[17, 20, 27, 28, 36, 44, 46]
PenicillinHigh[15]
PrilocainHigh[15]
RemifentanilHigh[33]
SevofluranHigh[4,17]
StreptomycinHigh[15]
TrimethoprimHigh[10, 42, 46]
Vitamin KHigh[10, 15, 17]
Amikacinsicher[6,18,31]
Bupivacainsicher[44]
Chloroquinsicher[2, 26]
Glycopyrrolatsicher[44]
Halothansicher[4, 17]
Heparinsicher[12, 34]
Ibuprofensicher[31]
Ketaminsicher[4, 17]
Mannitolsicher[12, 44]
N2Osicher[37, 40, 44]
Neostigminsicher[44]
Paracetamolsicher[6, 18, 31]
Parecoxibsicher[31]
Pethidinsicher[33]
Phenytoinsicher[6, 17, 18, 46]
Propofolsicher[2, 17, 37]
Rocuroniumsicher[44]
Succinylcholinsicher[15]
Sufentanilsicher[31]
Thiopentalsicher[15, 40]
Tramadolsicher[31]
AcetanilidHigh[6]
AcetazolamidHigh[15]
ASS (high dose)High[46]
Co-TrimoxazolHigh[10, 42, 46]
DapsonHigh[10, 15,17, 18, 46]
DiclofenacHigh[15]
DiazepamHigh[4, 15, 17]
GentamicinHigh[24]
LidocainHigh[15,17]
MethylenblauHigh[6,7, 15, 17, 18, 46]
MetoclopramidHigh[15]
NaphtalinHigh[6]
NitrofurantoinHigh[6, 10, 15, 17, 18, 46]
PenicillinHigh[15]
PhenazopyridinHigh[6, 10, 46]
Prilocain (EMLA-Creme)High[6, 16]
PrimaquinHigh[3,6,10,15,17,18,46]
Chinolon-Antibiotika, z. B. Ciprofloxacin High[6, 10, 15, 46]
RasburicaseHigh[8, 32, 46]
Sulfonamid-AntibiotikaHigh[3, 6, 10, 15, 17, 18]
Toluidinblau High[6, 15, 17, 18, 46]

* = in normalen therapeutischen Dosen und / oder bei milden G-6-PD-Varianten